Out of curiosity MistressLegato, what did you mean by that when you mentioned... ... cleared your throat in your last post?
It's all over the internet actually. Tokyopop came out with a contract that screwed over the rights of anyone who signed a comic artist/writer contract with them.
http://www.animenewsnetwork.com/news/2008-05-28/tokyopop-manga-pilot-pact-signs-away-legal-rights I can't find the better discussions of it right now. >___>
This might be slightly off topic but... right I'm taking a comic-making class that happens to be run by a Dark Horse editor, and they seem pretty cool. (The class is being run by my college, not Dark Horse.)
As far as length of story submission, she recommended submitting a one-shot first (one chapter or up to one volume), instead of trying to pitch your whole epic to them anyway. It's a matter of commitment; if you can hold up your end of the bargain with just the one-shot, they will be more likely to accept the long-term commitment with your long story.
They also insisted that you keep on submitting to them (or any other submissions department for any other publisher) often. Not so much flooding their mail with submissions and querries on whether or not they've looked at it, but periodically. If you have any sort of promise, they keep your stuff on file, and if you're genuinely improving, they'll see it.
She also said that self-publishing is indeed a good way to get started. It lets you practice and get used to deadlines and technique before actually landing the job. Also important, if you can generate enough fanbase with your self-publishing, they'd more readily agree signing you in. Dark Horse just signed the webcomic Applegeeks, and they have a few other webcomics.