Major/Classes: Take general core classes until your calling calls you. That's what I'm doing. (I've found my calling, but I'm going to try to find another one to study, since not many people make a living as a rock pianist, and I'm not banking on it)
PSU's a good school if your interested in Languages and Humanities.
UO is good if you're into art and architecture and parallel technical aspects of either.
OSU is good for Engineering, Physics, Comp Sci, etc
Willamette U is good if you're a hippy, it's also the closest out-of-town school.
Reed College is a great school. It's also really hard to get into.
UW is a great school all around, if you like Seattle.
The East coast has loads of good schools, but that would get really expensive really fast.
California has a plethora of good schools as well, but most of them are pretty far from Portland.
It kind of depends on who you are, what your grades and SAT/ACT scores look like, and where you think you're going to be happy. I've personally decided Portland is where I'm happy, so I'm going to try my damnedest to get into Reed, and I've applied to Willamette as my back-up. I'm going to consider applying to UO and PSU, but Willamette sent me a free application and seems to be the most bohemian of the three from what I've gathered.