Not that I have enough info from the poll to draw any conclusions, but I had an idea or two about how to handle this.
What if the entire game were handled in the form of themed sets? Each set would have around 75 cards, and you could pick out your favorite sets to create a deck tailored to your tastes. Here are some possible themes for sets:
Events (official convention events)
Fandom (fanspeak and inside references)
Anime (series and genres)
Gaming (video gaming and unplugged)
The Internet (memes and internet lingo)
Swag Bag (various objects of fan interest)
Staff (Kumori Con staff have a lot of inside jokes...)
To make sure nobody has to buy cards they don't need, a set of green cards would be available separately. It would also be around 75 cards, though, and I'd recommend using the original Apples to Apples green cards instead (if you have them).
Additionally, I think I may be ready to announce a name for this game; something shorter than what it's been called so far.